Prolonged high force high repetition pulling induces osteocyte apoptosis and trabecular bone loss in distal radius, while low force high repetition pulling induces bone anabolism
نویسندگان
چکیده
منابع مشابه
Protein High-Force Pulling Simulations Yield Low-Force Results
All-atom explicit-solvent molecular dynamics simulations are used to pull with extremely large constant force (750-3000 pN) on three small proteins. The introduction of a nondimensional timescale permits direct comparison of unfolding across all forces. A crossover force of approximately 1100 pN divides unfolding dynamics into two regimes. At higher forces, residues sequentially unfold from the...
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ژورنال
عنوان ژورنال: Bone
سال: 2018
ISSN: 8756-3282
DOI: 10.1016/j.bone.2018.02.014